In-silico analysis of Adenomatous Polyposis Coli (APC) gene in human cancers Adenomatous Polyposis Coli is (APC) serves as a key tumor suppressor gene by suppressing canonical Wnt signaling pathway which is essential for tumorigenesis. Mutation in APC has been observed in more that 80% of colorectal cancers and more than 90% of these mutations result […]

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March 27th, 2018

With the interest and expertise in infectious disease research, we are working on a project determining infection potential and genetic structure of microbes from healthcare and municipal wastes in Kathmandu. Healthcare waste is defined as all the wastes generated by healthcare facilities, medical laboratories and biomedical research facilities, as well as wastes from minor or scattered […]

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August 6th, 2017

Non-small cell lung carcinoma (NSLC) is one of the subtypes of lung cancer. Mutation in epidermal growth factor receptor (EGFR) is commonly found in NSLC patients, specifically in lung adenocarcinoma. Therefore, EGFR inhibitors may be used as an effective first line of chemotherapy to treat NSCLC. Two classes of EGFR inhibitor are available: Monoclonal antibodies […]

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August 5th, 2017

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